Reagent Kit HemeScreen® HRM Screening DNMT3A For use with HRM-enabled RT-PCR Machine / Cytopenia Panel 100 Tests
Precipio’s HemeScreen® offerings are Research Use Only (RUO) assays that screen for clinically actionable somatic mutations in targets of interest related to myeloproliferative disorders and haematological cancers
Product Specifications
Description
The reagents are designed to be used in a clinical diagnostic laboratory by suitably trained personnel testing DNA extracted from whole blood or bone marrow using a PCR-based method and High Resolution Melt (HRM) Analysis
DNMT3A (DNA methyltransferase 3A) mutation can be seen in AML and MDS; patients who have MDS with DNMT3A mutation have an increased chance of disease transformation to AML
DNMT3A mutation has poor prognosis for AML patients, and can be used to monitor treatment
Machine required HRM-enabled RT-PCR (example/ ThermoFisher Quantstudio 3 or higher)
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