Reagent Kit HemeScreen® HRM Screening ASXL1 For use with HRM-enabled RT-PCR Machine / Cytopenia Panel 100 Tests
Precipio’s HemeScreen® offerings are Research Use Only (RUO) assays that screen for clinically actionable somatic mutations in targets of interest related to myeloproliferative disorders and haematological cancers
Product Specifications
Description
The reagents are designed to be used in a clinical diagnostic laboratory by suitably trained personnel testing DNA extracted from whole blood or bone marrow using a PCR-based method and High Resolution Melt (HRM) Analysis
ASXL1 (additional sex combslike 1) mutations can be seen in myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), chronic myelomonocytic leukemia (CMML), refractory cytopenia, persistent cytopenia with early detection of MDS and AML
ASXL1 is often associated with RUNX1 cytogenetic abnormalities in both MDS and AML, as well as CEBPA in AML
Machine required HRM-enabled RT-PCR (example/ ThermoFisher Quantstudio 3 or higher)